Home destillation handbook

The discovery of efficacious new human therapeutic agents is one of humanity’s most vital

tasks. It is an enormously demanding activity that requires creativity, a vast range of scien-

tific knowledge, and great persistence. It is also an exceedingly expensive activity. In an

ideal world, no education would be complete without some exposure to the ways in which

new medicines are discovered and developed. For those young people interested in science

or medicine, such knowledge is arguably mandatory.

In this book, Douglas Johnson, Jie Jack Li, and their colleagues present a glimpse

into the realities and demands of drug discovery. It is both penetrating and authoritative.

The intended audience, practitioners and students of medicinal and synthetic chemistry,

can gain perspective, wisdom, and valuable factual knowledge from this volume. The

first two chapters of the book provide a clear view of the many complexities of drug dis-

covery, the numerous stringent requirements that any potential therapeutic molecule must

meet, the challenges and approaches involved in finding molecular structures that “hit” a

biological target, and the many facets of chemical synthesis that connect initial small-scale

laboratory synthesis with the evolution of a process for successful commercial production.

The remaining 15 chapters provide a wealth of interesting synthetic chemistry as applied

to the real world of the molecular medicine of cancer, infectious, cardiovascular, and

metabolic diseases. At the same time, each of these chapters illuminates the way in

which a first-generation therapeutic agent is refined and improved by the application of

medicinal chemistry to the discovery of second- and third-generation medicines.

The authors have produced a valuable work for which they deserve much credit. It is

another step in the odyssey of drug finders; a hardy breed that accepts the high-risk nature

of their prospecting task, the uncertainties at the frontier, and the need for good fortune, as

well as focus and sustained hard work. My ability to predict the future is no better than that

of others, but I think it is possible that a highly productive age of medicinal discovery lies

ahead, for three reasons: (1) the discovery of numerous important new targets for effective

disease therapy, (2) the increasing power of high-throughput screening and bio-target

structure-guided drug design in identifying lead molecules, and (3) the ever-increasing

sophistication of synthetic and computational chemistry.

E. J.

THE GREAT BIG

NARCOTICS COOKB

Complete guide 

Hydrochloric Acid

Handbook

Everything you need to know regarding finding and buying plants that contain

mescaline, DMT and harmala alkaloids, and also everything you need to know

about preparing them for traditional consumption or extracting pure alkaloids

from them.

These extraction methods are tried and tested, and have been selected for

simplicity. If you do not have laboratory grade equipment or chemicals,

instructions for easy to get DIY replacements are included.

Mescaline, DMT and harmala alkaloids are ancient non-addictive substances that

have been used safely for thousands of years. Don’t be a fool and confuse them

with dangerous drugs like methamphetamines or “bath salts

It is my pleasure to present you one of the finest treatises

since the publication of Avicenna's Canon of Medicine. In

the nearly one thousand years since then, the world has given

us Galileo, Marie Curie, Enrico Fermi, Werner von Braun

and of course ... Uncle Fester.

In Advanced Techniques of Clandestine Psychedelic &

Amphetamine Manufacture, Fester introduces and details

his breakthrough findings in what amounts to the application

of yet another branch of science to speed synthesis: electro-

chemistry . At the heart of these new syntheses the philoso-

pher's stone of crank cookery: ''The Fester Formula" - an

invention that is to amphetamines what breadmaking ma-

chines are to a freshly baked loaf of bread. What is normally

a time-consuming, laborious and somewhat messy operation

is reduced to a sort of "meth in a box." Don't be surprised to

see some version of it hawked on late night infomercials.

The DEA has recently estimated the total number of clandestine

LSD labs operating in the United States at only 100, with most of

them located in northern California. This alarmingly low number of

labs leaves the supply of LSD in this country at constant peril. Further,

the concentration of production in so few hands has left us awash in

a mediocre swill comparable to the beer spewed out by the major

brewers. The vast majority of acid is uniform, bland, low powered

and uninspiring.

This distressing situation results from the convergence of a series

of factors. The botanical sources of lysergic acid are not easily

available in large quantities. The actual production of LSD from

these botanical sources is a touchy and involved operation. The most

convenient and direct starting materials for acid production such as

lysergic acid or lysergamide are controlled substances and unavailable

directly to the public in any quantity. These roadblocks,however,

pale in comparison to the most important factor - the inaccessibility

of good information to those motivated to put it into action

Including Recipes for MDA, Ecstasy,

and Other Psychedelic Amphetamines

Revised and Expanded

SECllTSOF

MEfllAMPIiET AMINE

MANUFACTURE

Including Recipes for MOA, Ecstasy,

and Other Psychedelic Amphetamines

Revised and Expanded

BIH EDITION

by Uncle rester

This is a PDF version of The Drug Users Bible [Extended Edition]. It has

been provided free of charge in the interests of public safety. Some notes,

however, apply specifically to this formaat

PUBLISHER'S WARNING

This is NOT a manual for the compleat idiot. The procedures

referred to and described in this work assume a thorough knowledge

of advanced lab techniques in organic chemistry, and should not be

undertaken lightly by amateurs. Inexpert procedures can, among

other things, asphyxiate you, blow you up, set you (or your house)

on fire, and if the end product is imperfectly prepared, poison you

and your friends. If you don't know what you are doing, take this

book to someone who does. We would rather that we both made a

new friend than that we lost you as an old one.

Whizzology: Dr Nuke's Guide to the Amphetamine Family

DMT for the masses: updated 14-04-2008

how to make dmt

DMT handbook

LSD my problem child(Albert hoffman)

total syntheses 1

total syntheses 2.

This is part 1 of 6 of the second half of PiHKAL: A Chemical Love Story, by

Alexander Shulgin and Ann Shulgin. Please forgive any typos or misprints in this file;

further, because of ASCII limitations, many of the typographical symbols in the original

book could not be properly represented in these files. If you are seriously interested in

the chemistry contained in these files, you should order a copy of the book PiHKAL.

The book may be purchased for $22.95 ($18.95 + $4.00 postage and handling) from

Transform Press, Box 13675, Berkeley, CA 94701. California residents please add $1.38

State sales tax.

At the present time, restrictive laws are in force in the United States and it is very

difficult for researchers to abide by the regulations which govern efforts to obtain legal

approval to do work with these compounds in human beings.... No one who is lacking

legal authorization should attempt the of any of the compounds described in these files,

with the intent to give them to man. To do so is to risk legal action which might lead to

the tragic ruination of a life. It should also be noted that any person anywhere who

experiments on himself, or on another human being, with any of the drugs described

herin, without being familiar with that drug's action and aware of the physical and/or

mental disturbance or harm it might cause, is acting irresponsibly and immorally,

whether or not he is doing so within the bounds of the

n 1991 an unusual book with an unusual title first began to circulate

among an unusual set of people: those convinced that there were significant

psychological and spiritual benefits to be derived from the use of psyche-

delic drugs. PIHKAL: A Chemical Love Story, consisted of two parts: Book I

included a number of first-hand accounts of the use of a dozen or so

psychedelics with enough detail for the reader to get a good feeling for the

set and setting. Woven in with this was the story of how the authors, Ann

and Alexander (Sasha) Shulgin (under the pseudonymous cloak of Alice

and Shura) met, loved, and eventually married. Like all good love stories,

a triangular suspense resolves when a German woman, with whom Shura

was initially involved, eventually fades into the permanent past tense. In

Book II of PIHKAL, the structures and syntheses of nearly 200 chemical

compounds were given in "recipe" form followed in most cases by brief

evaluations of their psychic or physical effects by self-experimentation on

the part of various anonymous volunteers. The compounds of PIHKAL's

Book II are all in the class known as phenethylamines, which explains the

acronym in the title: Phenethylamines I Have Known And Loved.

The present book is based on the same format, but the compounds

of its Part II now fall into that other structural class to which almost all the

remaining psychedelics belong, the tryptamines. TIHKAL stands for

Tryptamines I Have Known And Loved. In TIHKAL, the human love triangle

is no longer present, and so the first half of the book consists rather of a rich

smorgasbord of narratives and essays concerning the origins and uses of

psychedelics. Here the natural products chemist can enjoy a delightful

ramble through the astonishing diversity of creatures — from fungi and

frogs to flowers — which contain DMT or its chemical near cousins. The

psychopharmacologist can wonder if a clue to the auditory hallucinations

so typical of schizophrenia can be found in the unique activity of DIPT. A

Jungian psychotherapist will be challenged by Alice's stories of the gentle

synergism exercised by a skilled therapist and the entactogen MDMA. And,

sadly, the civil libertarian may find reason to fear that something much like

The shulgin index vol.1

Our objective in presenting this volume was to produce an encyclopedia about a particular

group of psychedelic drugs, the phenethylamines. Phenethylamines are drugs with

profound mind-altering properties that we find both fascinating and rewarding. It is our

conviction that the varied potency, duration, and character of these many compounds

should be explored further, so that they may be rated as to efficacy and safety, and

become practical tools in the work of medical professionals and lay therapists, as well

as in the hands of spiritual guides and seekers. Their potential is great, but with great

benefit, there also may be great risks. In order to lay a solid foundation based on known

biochemistry, pharmacology, and toxicology, we have explored the available literature on

chemical, medical, and legal aspects of the known psychedelics, and attempted to present

that information so that future practitioners have a concise source of information to guide

further work.

Otto Snow - lsd25 & tryptamine synthese

Otto Snow - love drugs

thc, tropacocaine (otto snow)